Honing your edge.
If you fight wars where others possess the advantages, you will lose. You will feel as though you're pushing a cannon up the face of a cliff. You will burn a lot of money. You will suffer a lot of heartache. You will experience a lot of failure. Instead, you should dedicate a tremendous amount of time finding the area you're most competent in. This area of competence is rarely fashionable. In fact, the less fashionable it is the better because unfashionable industries experience less competition. It's a very simple strategy that few people have the discipline to execute. You find your edge. You spend your life honing that edge. You pick battles you know you can win.